Indiana Blood Center’s Immunohematology Reference Laboratory (IRL) is a highly specialized area that focuses its attention on the identification and resolution of red cell transfusion-related problems. It is an accredited Immunohematology Reference Laboratory by the American Association of Blood Banks (AABB) and maintains satisfactory standing with all inspection agencies. Below is the list of available tests and services that can be requested through the Immunohematology Reference Laboratory.

- Red cell antibody investigations
- Single to complex multiple antibodies
- Drug-dependant antibodies
- Antibodies to high- and low-incidence antigens
- Reagent-dependant reactivity
- Hemolytic disease of the newborn investigations
- Transfusion reactions investigations
- Aberrant or discrepant result investigations
- ABO discrepancies
- Discrepant red cell antigen typing
- Polyagglutination investigations
- Donor/Patient red cell phenotype (serologic and molecular) requests
- Parental evaluations (ABO/Rh, ABID, titer)
- Procurement of antigen-negative donor units